Should we consider Dupuytren's contracture as work-related? A review and meta-analysis of an old debate
Open Access
- 16 May 2011
- journal article
- research article
- Published by Springer Science and Business Media LLC in BMC Musculoskeletal Disorders
- Vol. 12 (1), 96
- https://doi.org/10.1186/1471-2474-12-96
Abstract
International audience BACKGROUND: In view of the conflicting opinions published, a meta-analysis was undertaken on epidemiological studies in order to assess any association between Dupuytren's contracture and work exposure. METHODS: Using the key words: "occupational disease", "work" and "Dupuytren contracture" without limitation on language or year of publication, epidemiological studies were selected from four databases (Pub-Med, Embase, Web of science, BDSP) after two rounds (valid control group, valid work exposure). A quality assessment list was constructed and used to isolate papers with high quality methodological criteria (scores of 13 or above, HQMC). Relevant associations between manual work, vibration exposure (at work) and Dupuytren's contracture were extracted from the articles and a metarisk calculated using the generic variance approach (meta-odds ratios, meta-OR). RESULTS: From 1951 to 2007, 14 epidemiological studies (including 2 cohort studies, 3 case-control studies, and 9 cross-sectional studies/ population surveys) were included. Two different results could be extracted from five studies (based on different types of exposure), leading to 19 results, 12 for manual work (9 studies), and 7 for vibration exposure (5 studies). Six studies met the HQMC, yielding 9 results, 5 for manual work and 4 for vibration exposure. Five studies found a dose-response relationship. The meta-OR for manual work was 2.02[1.57;2.60] (HQMC studies only: 2.01[1.51;2.66]), and the meta-OR for vibration exposure was 2.88 [1.36;6.07] (HQMC studies only: 2.14[1.59;2.88]). CONCLUSION: These results support the hypothesis of an association between high levels of work exposure (manual work and vibration exposure) and Dupuytren's contracture in certain casesThis publication has 37 references indexed in Scilit:
- The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and ElaborationPLoS Medicine, 2009
- Epidemiological Evaluation of Dupuytren's Disease Incidence and Prevalence Rates in Relation to EtiologyHAND, 2009
- An assessment of the effects of exposure to vibration, smoking, alcohol and diabetes on the prevalence of dupuytren's disease in 97,537 minersJournal of Hand Surgery (European Volume), 2007
- Dupuytren's ContractureThe New England Journal of Medicine, 2007
- Dupuytren's contracture unfoldedBMJ, 2006
- A Study of the Repeatability of the Diagnosis of Dupuytren’s Contracture and its Prevalence in the Grampian RegionJournal of Hand Surgery (European Volume), 1993
- Prevalence of Dupuytren’s Contracture and its Correlation with Degenerative Changes of the Hands and Feet and with Criteria of General HealthJournal of Hand Surgery (European Volume), 1993
- Quelques aspects épidémiologiques de la maladie de DupuytrenAnnales de Chirurgie de la Main, 1988
- Dupuytren's contracture in manual workers.Occupational and Environmental Medicine, 1982
- THE ÆTIOLOGY OF DUPUYTREN'S CONTRACTUREThe Lancet, 1951