Intravascular myopericytoma
- 2 October 2002
- journal article
- case report
- Published by Wiley in Journal of Cutaneous Pathology
- Vol. 29 (9), 557-561
- https://doi.org/10.1034/j.1600-0560.2002.290908.x
Abstract
Myopericytoma is a benign tumor composed of cells that show apparent differentiation towards putative perivascular myoid cells called myopericytes. It arises most commonly in the dermis or subcutaneous tissue of the extremities in adults. We describe a myopericytoma that was unusual in its intravascular location. A 54-year-old man presented with a 10-year history of a painful slowly growing 1.5-cm nodule in the subcutaneous tissue of the thigh. Histologic examination of the excised lesion showed that is was entirely contained within the lumen of a vein. It was composed of a proliferation of myoid-appearing spindle cells, which were arranged in a striking concentric pattern around numerous blood vessels, in a manner that accentuated the vessel walls. This pattern is characteristic of myopericytoma. In some areas, fascicles of spindle cells, embedded in a myxoid stroma, bulged into the lumina of lesional vessels, reminiscent of myofibroma/myofibromatosis. Lesional spindle cells were diffusely positive for smooth muscle actin, focally positive for CD34 and were negative for desmin, cytokeratin, S100 protein, HMB-45 and CD31. This case illustrates that myopericytoma can be entirely intravascular in its location.Keywords
This publication has 33 references indexed in Scilit:
- Intravascular angioleiomyomaJournal of Cutaneous Pathology, 1999
- Myofibromatosis in Adults, Glomangiopericytoma, and MyopericytomaThe American Journal of Surgical Pathology, 1998
- Cutaneous adult myofibroma: a vascular neoplasmJournal of Cutaneous Pathology, 1996
- Mechanism of pain and cytoskeletal properties in angioleiomyomas: An immunohistochemical studyPathology International, 1994
- Unusual Variants of Nodular FasciitisThe American Journal of Dermatopathology, 1993
- Glomeruloid Hemangioma A Distinctive Cutaneous Lesion of Multicentric Castlemanʼs Disease Associated with POEMS SyndromeThe American Journal of Surgical Pathology, 1990
- Myofibromatosis in AdultsThe American Journal of Surgical Pathology, 1989
- Intravascular fasciitisThe American Journal of Surgical Pathology, 1980