MicroRNA profile changes in human immunodeficiency virus type 1 (HIV-1) seropositive individuals
Open Access
- 29 December 2008
- journal article
- research article
- Published by Springer Science and Business Media LLC in Retrovirology
- Vol. 5 (1), 1-9
- https://doi.org/10.1186/1742-4690-5-118
Abstract
MicroRNAs (miRNAs) play diverse roles in regulating cellular and developmental functions. We have profiled the miRNA expression in peripheral blood mononuclear cells from 36 HIV-1 seropositive individuals and 12 normal controls. The HIV-1-positive individuals were categorized operationally into four classes based on their CD4+ T-cell counts and their viral loads. We report that specific miRNA signatures can be observed for each of the four classes.Keywords
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