THE DETERMINATION OF THE GLOMERULAR FILTRATION BY THE ENDOGENOUS CREATININE CLEARANCE 1

Abstract

After a short discussion of Popper''s method for the detn. of creatinine, the results of 3 series of expts., performed to show the suitability of this method for the detn. of the glomerular filtration, are reported involving comparisons between the endogenous creatinine clearance and the inulin clearance; the endogenous creatinine clearance and the exogenous creatinine clearance; and the endogenous creatinine clearance and the urea clearance. With Popper''s method the glomerular filtration can be detd. much more easily by the endogenous creatinine clearance than with any other method. The detn. of plasma creatinine is of high diagnostic value because it makes possible the estimation of the glomerular filtration rate by one simple blood analysis. This simple method can therefore replace any other test of glomerular function. It is a further step in simplifying the diagnosis of renal function. The conception of reabsorption uremia is discussed, but cannot be maintained for the explanation of the retention of urea in cases of glomerulonephritis. except for the cases of functional disorganization of the kidney.