A Clinicopathological study on combined hepatocellular and cholangiocarcinoma
- 1 August 1996
- journal article
- Published by Wiley in Journal of Gastroenterology and Hepatology
- Vol. 11 (8), 758-764
- https://doi.org/10.1111/j.1440-1746.1996.tb00327.x
Abstract
We clinicopathologically studied 23 surgically resected cases of combined hepatocellular and cholangiocarcinoma (HCC-CC). The frequency of this cancer in our subjects, who had primary liver cancer and who underwent hepatectomy, was 6.3%. The mean age of patients was 64.0 years old and the male: female ratio was 1.9:1. Serum α-fetoprotein was positive in 70% of cases and its levels were relatively low (≤ 1000 ng/mL) in most cases. The positive rate of serum carcinoembryonic antigen was 18% and its levels were also low. In regard to hepatitis virus markers, 17% of the 20 combined HCC-CC cases were positive to HBs antigen and 70% were positive to the HCV antibody. Of the 23 combined HCC-CC cases, 9 cases (39%) were associated with liver cirrhosis. Tumours were classified macroscopically into a separated type (HCC and CC are clearly separated 17%), a HCC-predominant type (resembles HCC 49%), and a CC-predominant type (resembles CC 34%). The separated and HCC-predominant types were associated with liver cirrhosis in 50 and 55% of cases, respectively. These cases with liver cirrhosis presented the features of HCC more apparently, while those without liver cirrhosis presented the features of CC. Histologically, all cases were classified into either Type I (HCC and CC were clearly distinguished; 17%), Type II (HCC and CC were contiguous and shared transitional features; 66%), and Type III (cancer cells were able to be evaluated as either HCC or CC and were considered to be an intermediate type; 17%). Immunohistological stains for cytokeratin were useful to distinguish HCC and CC. Specifically, CC was positive to cytokeratin 7 and 19. The tumour, in which HCC and CC were almost indistinguishable, such as Type III), indicates the presence of intermediate tumour cells that can differentiate either to HCC or CC.Keywords
This publication has 12 references indexed in Scilit:
- Pathomorphology of advanced hepatocellular carcinomaPublished by Springer Science and Business Media LLC ,1992
- Immunohistochemistry in the Differential Diagnosis of Liver CarcinomasThe American Journal of Surgical Pathology, 1991
- The development of the intrahepatic bile ducts in man: A keratin-immunohistochemical studyHepatology, 1988
- A new human hepatocellular carcinoma cell line (KYN-1) with a transformation to adenocarcinomaIn Vitro Cellular & Developmental Biology, 1986
- Clinicopathological study of combined hepatocellular and cholangiocarcinoma.Kanzo, 1986
- ELECTRON MICROSCOPY OF THE LIVERPublished by Elsevier BV ,1963
- THE MICRO-ANATOMY OF THE SMALLEST BILIARY PATHWAYS IN MOUSE LIVER TISSUECells Tissues Organs, 1961
- Cancer and Human RacesThe American Journal of Cancer, 1937
- Primary duplex liver carcinomaThe American Journal of Surgery, 1932
- PRIMARY CARCINOMA OF THE LIVERThe American Journal of the Medical Sciences, 1903