SK-N-BE(2) cells were treated with NEN for 16hrs. (A) Upregulated and (B) downregulated genes from RNA-seq data (n=3) (sleuth q-value < 0.05 and fold change estimate b > abs(ln(2))). (C) The top 10 gene ontology (GO) pathways enriched from upregulated genes by using DAVID analysis. (D) The top 10 gene ontology (GO) pathways enriched from downregulated genes by using DAVID analysis.