Neuropeptides in the Regulation of Female Genital Smooth Muscle Contractility
- 11 January 1983
- journal article
- research article
- Published by Wiley in Acta Obstetricia et Gynecologica Scandinavica
- Vol. 62 (6), 591-592
- https://doi.org/10.3109/00016348309156254
Abstract
The mammalian female genital tract is innervated with nerve fibers containing vasoactive intestinal polypeptide (VIP), substance P, enkephalins and somatostatin. The effect of these peptides was studied by in-vitro tension recordings on smooth muscle preparations from the uterine body, cervix and Fallopian tube of 18 women. Substance P (10-5-10-6 mol/l) had a dose-dependent stimulatory effect. VIP displayed a dose-dependently inhibitory effect on the substance P evoked contractions. Somatostatin, met-enkephalin and leu-enkephalin had neither stimulatory nor inhibitory effect. Substance P and VIP may participate in a dual nervous control of genital smooth muscle contractions.This publication has 4 references indexed in Scilit:
- Vasoactive intestinal polypeptide (VIP): Effect on rabbit uterine smooth muscle in vivo and in vitroActa Physiologica Scandinavica, 1981
- Vasoactive Intestinal Polypeptide (VIP) in the Human Female Reproductive Tract: Distribution and Motor EffectsBiology of Reproduction, 1981
- Origin and distribution of VIP (Vasoactive Intestinal Polypeptide)-nerves in the genito-urinary tractCell and tissue research, 1980
- Substance P: A Polypeptide of Possible Physiological Significance, Especially Within the Nervous SystemPublished by Elsevier BV ,1962