Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences
- 1 June 1984
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 309 (5971), 757-762
- https://doi.org/10.1038/309757a0
Abstract
Two related, but distinct, cDNA clones have been isolated and sequenced from a functional murine cytotoxic T-lymphocyte clone. The genes corresponding to these cDNA are expressed and rearranged specifically in T cells and both have similarities to immunoglobulin variable and constant region genes. It is concluded that these genes code for the two subunits of the heterodimeric antigen receptor on the surface of the T cell; its complete deduced primary structure is presented.Keywords
This publication has 21 references indexed in Scilit:
- The mouse T cell receptor: Structural heterogeneity of molecules of normal T cells defined by XenoantiserumCell, 1983
- The human T cell receptor: Appearance in ontogeny and biochemical relationship of α and β subunits on IL-2 dependent clones and T cell tumorsCell, 1983
- The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody.The Journal of Experimental Medicine, 1983
- Somatic generation of antibody diversityNature, 1983
- The T lymphocyte antigen receptor—paradigm lostNature, 1982
- Major histocompatibility complex-restricted antigen presentation to antigen-reactive T cells by B lymphocyte tumor cells.The Journal of Experimental Medicine, 1981
- H-2 antigens of the thymus determinelymphocyte specificityThe Journal of Experimental Medicine, 1978
- On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?The Journal of Experimental Medicine, 1978
- Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic systemNature, 1974
- CELL INTERACTIONS BETWEEN HISTOINCOMPATIBLE T AND B LYMPHOCYTESThe Journal of Experimental Medicine, 1973