Survival and Prognostic Factors in Malignant Pleural Mesothelioma: A Retrospective Study of 314 patients in the West Part of Japan
Open Access
- 26 August 2010
- journal article
- research article
- Published by Oxford University Press (OUP) in Japanese Journal of Clinical Oncology
- Vol. 41 (1), 32-39
- https://doi.org/10.1093/jjco/hyq159
Abstract
The objective in our study was to examine baseline and other characteristics associated with survival in patients with malignant pleural mesothelioma in Japan. Three hundred and fourteen patients with an adjudicated diagnosis of mesothelioma were examined. Survival was evaluated by the Kaplan–Meier method with the log-rank test. The Cox model was used to estimate the hazard ratio for the possible prognostic factors. Of 314 patients, 223 (71%) died and only 40 (13%) were still alive at the end of the observation period starting from the day of diagnosis, while 51 (16%) were transferred to other hospitals or had the last health service contact before the end of the study period yielding the median survival of 308 days. In the multivariate analysis, age older than 70 years (hazard ratio = 2.17; 95% confidence interval, 1.36–3.46), non-epithelioid type (hazard ratio = 1.58; 95% confidence interval, 1.15–2.18), poor performance status (hazard ratio = 3.22; 95% confidence interval, 1.19–8.74), high white blood cell count (hazard ratio = 1.49; 95% confidence interval, 0.99–2.26) and high C-reactive protein level (hazard ratio = 1.80; 95% confidence interval, 1.06–3.06) were negatively associated with survival, after adjustment for other factors. Some baseline conditions including old age, poor performance status, non-epithelioid type, high white blood cell count and high C-reactive protein level were determinants of poor survival of patients with malignant mesothelioma.Keywords
This publication has 17 references indexed in Scilit:
- Malignant mesothelioma: current status and perspective in Japan and the worldGeneral Thoracic and Cardiovascular Surgery, 2008
- Prognostic Factors in the Treatment of Malignant Pleural Mesothelioma at a Large Tertiary Referral CenterJournal of Thoracic Oncology, 2007
- Incidence and Survival of Mesothelioma in Osaka, JapanJapanese Journal of Clinical Oncology, 2006
- Macroscopic Complete Resection: The Goal of Primary Surgery in Multimodality Therapy for Pleural MesotheliomaJournal of Thoracic Oncology, 2006
- Assessment of nutritional status and prognosis in advanced cancer: interleukin-6, C-reactive protein, and the prognostic and inflammatory nutritional index. By Declan Walsh et al. Supportive Care in Cancer (2003) 11:60?62Supportive Care in Cancer, 2003
- Predictive and prognostic factors in malignant pleural mesotheliomaCurrent Opinion in Oncology, 2003
- Prognostic factors for malignant mesothelioma in 142 patients: validation of CALGB and EORTC prognostic scoring systemsThorax, 2000
- Factors Predictive of Survival Among 337 Patients With Mesothelioma Treated Between 1984 and 1994 by the Cancer and Leukemia Group BSocial psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 1998
- The Treatment of Malignant Mesothelioma of the PleuraAmerican Journal of Clinical Oncology, 1990
- Malignant pleural mesothelioma in western Glasgow 1980-6.Thorax, 1989