how functions in leg development during Drosophila metamorphosis
Open Access
- 17 July 2006
- journal article
- patterns and-phenotypes
- Published by Wiley in Developmental Dynamics
- Vol. 235 (8), 2248-2259
- https://doi.org/10.1002/dvdy.20852
Abstract
The Drosophila how gene encodes a KH RNA binding protein with strong similarity to GLD-1 from nematodes and QK1 from mice. Here, we investigate the function of how during metamorphosis. We show that how RNA and protein are present in a variety of tissues, and phenotypic analyses of how mutants reveal multiple lethal phases and defects during metamorphosis. In addition to previously reported abnormalities in muscle and wing development, how mutants exhibit defects in leg development. how mutant leg imaginal discs undergo cell shape changes associated with elongation, but are oriented improperly, do not evert normally, and often remain incased in peripodial epithelium longer than normal. Consequently, how mutants exhibit short, crooked legs. Our findings suggest that how functions in interactions between imaginal epithelium, peripodial epithelium, and larval epidermal cells during imaginal disc eversion. Developmental Dynamics 235:2248–2259, 2006.Keywords
This publication has 44 references indexed in Scilit:
- Invasive Cell Behavior during Drosophila Imaginal Disc Eversion Is Mediated by the JNK Signaling CascadeDevelopmental Cell, 2004
- Rho-LIM Kinase Signaling Regulates Ecdysone-Induced Gene Expression and Morphogenesis during Drosophila MetamorphosisCurrent Biology, 2004
- Orphan nuclear receptor βFTZ-F1 is required for muscle-driven morphogenetic events at the prepupal–pupal transition in Drosophila melanogasterDevelopmental Biology, 2003
- Leaving the neighborhood: molecular mechanisms involved during epithelial‐mesenchymal transitionBioEssays, 2001
- Drosophila peripodial cells, more than meets the eye?BioEssays, 2001
- Molecular Characterization of the 71E Late Puff inDrosophila melanogasterReveals a Family of Novel GenesJournal of Molecular Biology, 1996
- Searching for pattern and mutation in the Drosophila genome with a P-lacZ vector.Genes & Development, 1989
- Pupation in drosophila melanogaster and the effect of theLethalcryptocephal mutationDevelopmental Genetics, 1984
- Ecdysteroid titers during pupal and adult development in Drosophila melanogasterDevelopmental Biology, 1982
- A histological and ultrastructural analysis of developmental defects produced by the mutation, lethal(1)myospheroid, in Drosophila melanogasterDevelopmental Biology, 1981