Short Communication: From Wasting to Obesity: Initial Antiretroviral Therapy and Weight Gain in HIV-Infected Persons
- 1 March 2013
- journal article
- research article
- Published by Mary Ann Liebert Inc in AIDS Research and Human Retroviruses
- Vol. 29 (3), 435-440
- https://doi.org/10.1089/aid.2012.0234
Abstract
Data on weight gain and the progression to overweight/obesity in HIV-infected persons during initial combination antiretroviral therapy (cART) are limited, and comparisons to the general population are inconclusive. Weight and body mass index (BMI) changes were studied in HIV-infected adults who remained on initial cART for 12 consecutive months and in an HIV-uninfected cohort receiving care at Duke University Medical Center between 1998 and 2008. Overweight/obesity was defined as BMI ≥25 kg/m2. Variables were analyzed by Chi-square and Student's t-tests. Ninety-two HIV-infected persons (median age 38.2 years) met inclusion criteria. Weight and BMI increased during 12 months of cART (80.0 to 84.4 kg, p2, pp=0.04), in persons treated with protease inhibitor (PI)-based cART compared to non-PI-based cART (9.0 vs. 2.7 kg, p=0.001), and in persons with a pretreatment CD4 count 3 compared to ≥200 cells/mm3 (8.9 vs. 0.3 kg, pp=0.002). HIV-infected persons had a lower prevalence of pretreatment overweight/obesity compared to 94 age-matched control subjects (52% vs. 91%, p0.9) during 12 months in the control cohort. Management should anticipate excess weight gain during the first year of cART in persons who are female, have a pretreatment CD4 3, or will initiate PI-based cART.Keywords
This publication has 13 references indexed in Scilit:
- Increasing Rates of Obesity among HIV-Infected Persons during the HIV EpidemicPLOS ONE, 2010
- Endothelial Activation Markers Are Linked to HIV Status and Are Independent of Antiretroviral Therapy and LipoatrophyJAIDS Journal of Acquired Immune Deficiency Syndromes, 2008
- Obesity among Patients with HIV: The Latest EpidemicAIDS Patient Care and STDs, 2008
- The use of the Framingham equation to predict myocardial infarctions in HIV‐infected patients: comparison with observed events in the D:A:D StudyHIV Medicine, 2006
- Changes in Weight and Lean Body Mass during Highly Active Antiretroviral TherapyClinical Infectious Diseases, 2004
- Obesity Is an Important Determinant of Baseline Serum C-Reactive Protein Concentration in Monozygotic Twins, Independent of Genetic InfluencesCirculation, 2004
- C-Reactive Protein and Other Circulating Markers of Inflammation in the Prediction of Coronary Heart DiseaseThe New England Journal of Medicine, 2004
- Combination Antiretroviral Therapy and the Risk of Myocardial InfarctionThe New England Journal of Medicine, 2003
- Coronary Heart Disease in HIV-Infected IndividualsJAIDS Journal of Acquired Immune Deficiency Syndromes, 2003
- Do Protease Inhibitors Increase the Risk for Coronary Heart Disease in Patients With HIV-1 Infection?JAIDS Journal of Acquired Immune Deficiency Syndromes, 2002