A case-based discussion on a patient with non-otogenic fungal skull base osteomyelitis: pitfalls in diagnosis
- 1 January 2013
- journal article
- case report
- Published by Cambridge University Press (CUP) in The Journal of Laryngology & Otology
- Vol. 127 (8), 817-821
- https://doi.org/10.1017/s002221511300145x
Abstract
Objective: To discuss the diagnostic pitfalls and limitations of imaging investigations in non-otogenic skull base osteomyelitis.Case report: This paper reports a fatal case of non-otogenic fungal skull base osteomyelitis in an immunosuppressed patient. The patient initially presented with headache and later diplopia during multiple hospital admissions. A retrospective review of the initial imaging studies of his skull base revealed subtle signs of early infection at the inferior portion of the nasopharynx. Biopsies were taken from the posterior nasopharyngeal wall. Fungal cultures isolated Aspergillus fumigatus and mucor species.Conclusion: The insidious onset of the clinical features and the limitations of the currently available investigations make early diagnosis of skull base osteomyelitis difficult. This case highlights that skull base osteomyelitis should be suspected in immunocompromised patients with subtle radiological abnormalities on initial imaging. There is still controversy regarding the most accurate method of investigation for early diagnosis, and quite often multiple imaging modalities are required.Keywords
This publication has 16 references indexed in Scilit:
- Central or Atypical Skull Base Osteomyelitis: Diagnosis and TreatmentJournal of Neurological Surgery Part B: Skull Base, 2009
- Radiological and radionuclide investigation of malignant otitis externaThe Journal of Laryngology & Otology, 2005
- Masked pseudomonal skull base osteomyelitis presenting with a bilateral Xth cranial nerve palsyThe Journal of Laryngology & Otology, 2002
- Osteomyelitis of the base of the skull secondary to AspergillusAmerican Journal of Otolaryngology, 1997
- Osteomyelitis of the Skull BaseNeurosurgery, 1992
- Management of osteomyelitis of the skull baseThe Laryngoscope, 1989
- Atypical osteomyelitis of the skull baseThe Laryngoscope, 1989
- Osteomyelitis of the base of the skullThe Laryngoscope, 1986
- Chronic osteomyelitis: monitoring by 99mTc phosphate and 67Ga citrate imagingAmerican Journal of Roentgenology, 1985
- MucormycosisAnnals of Internal Medicine, 1980