Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR
Top Cited Papers
- 30 October 2010
- journal article
- review article
- Published by Elsevier BV in Advanced Drug Delivery Reviews
- Vol. 62 (13), 1238-1249
- https://doi.org/10.1016/j.addr.2010.08.006
Abstract
No abstract availableKeywords
This publication has 142 references indexed in Scilit:
- Hepatocyte Nuclear Factor 4α Regulates Rifampicin-Mediated Induction ofCYP2CGenes in Primary Cultures of Human HepatocytesDrug Metabolism and Disposition, 2010
- The Structural Basis of Pregnane X Receptor Binding PromiscuityBiochemistry, 2009
- Methadone Induces the Expression of Hepatic Drug-Metabolizing Enzymes through the Activation of Pregnane X Receptor and Constitutive Androstane ReceptorDrug Metabolism and Disposition, 2009
- Pyrethroid insecticides: Isoform-dependent hydrolysis, induction of cytochrome P450 3A4 and evidence on the involvement of the pregnane X receptorToxicology and Applied Pharmacology, 2009
- Regulation of Tissue-Specific Carboxylesterase Expression by Pregnane X Receptor and Constitutive Androstane ReceptorDrug Metabolism and Disposition, 2009
- Nuclear Translocation of Adenoviral-Enhanced Yellow Fluorescent Protein-Tagged-Human Constitutive Androstane Receptor (hCAR): A Novel Tool for Screening hCAR Activators in Human Primary HepatocytesDrug Metabolism and Disposition, 2009
- Induction of Mouse UDP-Glucuronosyltransferase mRNA Expression in Liver and Intestine by Activators of Aryl-Hydrocarbon Receptor, Constitutive Androstane Receptor, Pregnane X Receptor, Peroxisome Proliferator-Activated Receptor α, and Nuclear Factor Erythroid 2-Related Factor 2Drug Metabolism and Disposition, 2009
- Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytesNucleic Acids Research, 2009
- Dexamethasone suppresses the expression of multiple rat carboxylesterases through transcriptional repression: Evidence for an involvement of the glucocorticoid receptorToxicology, 2008
- Phenytoin Induction of the Cyp2c37 Gene Is Mediated by the Constitutive Androstane ReceptorDrug Metabolism and Disposition, 2006