Oligonucleotide/oligosaccharide-binding fold proteins: a growing family of genome guardians
- 6 May 2010
- journal article
- review article
- Published by Informa UK Limited in Critical Reviews in Biochemistry and Molecular Biology
- Vol. 45 (4), 266-275
- https://doi.org/10.3109/10409238.2010.488216
Abstract
The maintenance of genomic stability relies on the coordinated action of a number of cellular processes, including activation of the DNA-damage checkpoint, DNA replication, DNA repair, and telomere homeostasis. Many proteins involved in these cellular processes use different types of functional modules to regulate and execute their functions. Recent studies have revealed that many DNA-damage checkpoint and DNA repair proteins in human cells possess the oligonucleotide/oligosaccharide-binding (OB) fold domains, which are known to bind single-stranded DNA in both prokaryotes and eukaryotes. Furthermore, during the DNA damage response, the OB folds of the human checkpoint and DNA repair proteins play critical roles in DNA binding, protein complex assembly, and regulating protein–protein interactions. These findings suggest that the OB fold is an evolutionarily conserved functional module that is widely used by genome guardians. In this review, we will highlight the functions of several well-characterized or newly discovered eukaryotic OB-fold proteins in the DNA damage response.Keywords
This publication has 92 references indexed in Scilit:
- POT1–TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocationThe EMBO Journal, 2010
- An RPA-Related Sequence-Specific DNA-Binding Subunit of Telomerase Holoenzyme Is Required for Elongation Processivity and Telomere MaintenanceMolecular Cell, 2009
- Conserved Telomere Maintenance Component 1 Interacts with STN1 and Maintains Chromosome Ends in Higher EukaryotesMolecular Cell, 2009
- SOSS Complexes Participate in the Maintenance of Genomic StabilityMolecular Cell, 2009
- Physical Interaction between Replication Protein A (RPA) and MRN: Involvement of RPA2 Phosphorylation and the N-Terminus of RPA1Biochemistry, 2009
- The BRC Repeats of BRCA2 Modulate the DNA-Binding Selectivity of RAD51Cell, 2009
- ATR: an essential regulator of genome integrityNature Reviews Molecular Cell Biology, 2008
- Single-stranded DNA-binding protein hSSB1 is critical for genomic stabilityNature, 2008
- Rad52-mediated DNA annealing after Rad51-mediated DNA strand exchange promotes second ssDNA captureThe EMBO Journal, 2006
- Insights into DNA recombination from the structure of a RAD51–BRCA2 complexNature, 2002