The gastric precancerous cascade
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Open Access
- 28 October 2011
- journal article
- Published by Wiley in Journal of Digestive Diseases
- Vol. 13 (1), 2-9
- https://doi.org/10.1111/j.1751-2980.2011.00550.x
Abstract
Invasive gastric carcinoma is preceded by a cascade of precancerous lesions. The first recognized histologic change is active chronic inflammation, which may persist as such: non‐atrophic chronic gastritis (no gland loss), or advance to multifocal atrophic gastritis (MAG), the first real step in the precancerous cascade. The following steps are: intestinal metaplasia (first “complete” and then “incomplete”); dysplasia, first low grade and then high grade (equivalent to “carcinoma in situ”). The following step is invasive carcinoma, which is thought to be associated with degradation of the intercellular matrix.Keywords
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