Modular Synthesis of Cyclic Peptidomimetics Inspired by γ-Turns
- 11 February 2005
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 7 (6), 1059-1062
- https://doi.org/10.1021/ol047323a
Abstract
A series of peptidomimetics based on a γ-turn motif were synthesized using a modular approach, in which N-protected piperidones were reacted with a selection of 2-hydroxyalkyl azides derived from common l-amino acids. Hydrolysis of the initially formed iminium ethers afforded the targeted series of substituted 1,4-diazepin-5-ones.Keywords
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