PHOTOSENSITIZED OXIDATION OF BIOMATERIALS and RELATED MODEL COMPOUNDS
- 1 July 1989
- journal article
- Published by Wiley in Photochemistry and Photobiology
- Vol. 50 (1), 29-35
- https://doi.org/10.1111/j.1751-1097.1989.tb04126.x
Abstract
Aluminium trisulfonatophthalocyanine (A1PCS), a dye being widely advocated for use in photodynamic therapy, produces singlet oxygen with a quantum yield of 0.34 in oxygenated water at pH 7. Triplet A1PCS abstracts an electron from a variety of amines and phenols, the rate of electron transfer depending upon the thermodynamic driving force, forming the A1PCS radical anion. This latter species reduces molecular oxygen to superoxide ions with high efficiency. The triplet state also abstracts an electron from biological components, including NADH, vitamin C, cysteine, methionine, tyrosine, tryptophan, uracil, and guanine, but not from DNA. These results suggest that photoinduced electron abstraction from appropriate biomaterials could compete with singlet oxygen production under in vivo conditions.Keywords
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