Efficacy of metaphylactic florfenicol therapy during natural outbreaks of bovine respiratory disease
- 30 September 2008
- journal article
- Published by Wiley in Journal of Veterinary Pharmacology and Therapeutics
- Vol. 31 (5), 479-487
- https://doi.org/10.1111/j.1365-2885.2008.00981.x
Abstract
The efficacy of an injectable formulation of florfenicol (300 mg/mL) as metaphylactic control of naturally occurring bovine respiratory disease (BRD) was evaluated in two double‐blind randomly controlled field studies on two Dutch veal calf herds (A and B). Cattle aged not older than 3 months and in the direct presence of calves with clinical respiratory disease were randomly allocated to treatment with 40 mg/kg florfenicol subcutaneously (s.c.) a positive control treatment (12.5 mg/kg tilmicosin p.o. twice daily for five consecutive days in herd A, and 12.5 mg/kg doxycycline p.o. twice daily for five consecutive days in herd B), or a negative control (one placebo saline s.c. administration on D0). The predominant respiratory pathogens present in pretreatment respiratory samples from affected animals were Mycoplasma bovis and Pasteurella multocida in outbreaks A and B, respectively. Metaphylactic administration of florfenicol resulted in a statistically significant weight gain, decreased rectal temperature for five consecutive days after treatment and decreased metaphylactic failure percentages compared with both positive and negative control groups. In summary, these studies demonstrated that a single s.c. injection of florfenicol is effective and practical for control of the bacterial component of BRD in veal calves.Keywords
This publication has 11 references indexed in Scilit:
- Recovery of Moraxella ovis from the bovine respiratory tract and differentiation of Moraxella species by tDNA-intergenic spacer PCRVeterinary Microbiology, 2007
- Old dogs that learn new tricks: Modified antimicrobial agents that escape pre-existing resistance mechanismsInternational Journal of Medical Microbiology, 2006
- Naturally OccurringMycoplasma Bovis—Associated Pneumonia and Polyarthritis in Feedlot Beef CalvesJournal of Veterinary Diagnostic Investigation, 2006
- Variability in Acquired Resistance ofPasteurellaandMannheimiaIsolates from the Nasopharynx of Calves, with Particular Reference to Different Herd TypesMicrobial Drug Resistance, 2005
- Antibiotic susceptibilities of recent isolates ofMycopasma bovisin BelgiumVeterinary Record, 2003
- Mycoplasma bovis: disease, diagnosis, and controlResearch in Veterinary Science, 2002
- Effects of vaccination prior to transit and administration of florfenicol at time of arrival in a feedlot on the health of transported calves and detection ofMannheimia haemolyticain nasal secretionsAmerican Journal of Veterinary Research, 2002
- Antimicrobial resistance in Pasteurella and Mannheimia: epidemiology and genetic basisVeterinary Research, 2001
- Use of antimicrobials in veterinary medicine and mechanisms of resistanceVeterinary Research, 2001
- Risk factors for bovine respiratory disease in dairy youngstock in The Netherlands: the perception of expertsLivestock Production Science, 2000