Overview of Biological Mechanisms and Applications of Three Murine Models of Bone Repair: Closed Fracture with Intramedullary Fixation, Distraction Osteogenesis, and Marrow Ablation by Reaming
Open Access
- 2 March 2015
- journal article
- review article
- Published by Wiley in Current Protocols in Mouse Biology
- Vol. 5 (1), 21-34
- https://doi.org/10.1002/9780470942390.mo140166
Abstract
Fractures are one of the most common large‐organ, traumatic injuries in humans, and osteoporosis‐related fractures are the fastest growing health care problem of aging. Elective orthopedic surgeries of the bones and joints also represent some of most common forms of elective surgeries performed. Optimal repair of skeletal tissues is necessary for successful outcomes of these many different orthopedic surgical treatments. Research focused on post‐natal skeletal repair is therefore of immense clinical importance and of particular relevance in situations in which bone tissue healing is compromised due to the extent of tissue trauma or specific medical co‐morbidities. Three commonly used murine surgical models of bone healing, closed fracture with intramedullary fixation, distraction osteogenesis (DO), and marrow ablation by reaming, are presented. The biological aspects of these models are contrasted and the types of research questions that may be addressed with these models are presented. © 2015 by John Wiley & Sons, Inc.Keywords
This publication has 86 references indexed in Scilit:
- In Vivo Fate Mapping Identifies Mesenchymal Progenitor CellsThe International Journal of Cell Cloning, 2011
- The biology of fracture healingInjury, 2011
- Complementary interplay between matrix metalloproteinase-9, vascular endothelial growth factor and osteoclast function drives endochondral bone formationDisease Models & Mechanisms, 2010
- Rejuvenation of the inflammatory system stimulates fracture repair in aged miceJournal of Orthopaedic Research, 2010
- Micro-computed tomography assessment of fracture healing: Relationships among callus structure, composition, and mechanical functionBone, 2009
- Skeletal Cell Fate Decisions Within Periosteum and Bone Marrow During Bone RegenerationJournal of Bone and Mineral Research, 2009
- Modulation of the Inflammatory Response for Enhanced Bone Tissue RegenerationTissue Engineering, Part B: Reviews, 2008
- Bone Formation During Distraction Osteogenesis Is Dependent on Both VEGFR1 and VEGFR2 SignalingJournal of Bone and Mineral Research, 2008
- Diminished Bone Formation During Diabetic Fracture Healing is Related to the Premature Resorption of Cartilage Associated With Increased Osteoclast ActivityJournal of Bone and Mineral Research, 2007
- Ischemia leads to delayed union during fracture healing: A mouse modelJournal of Orthopaedic Research, 2006