Is Adenosine Action Common Ground for NREM Sleep, Torpor, and Other Hypometabolic States?
- 1 May 2018
- journal article
- review article
- Published by American Physiological Society in Physiology
- Vol. 33 (3), 182-196
- https://doi.org/10.1152/physiol.00007.2018
Abstract
This review compares two states that lower energy expenditure: non-rapid eye movement (NREM) sleep and torpor. Knowledge on mechanisms common to these states, and particularly on the role of adenosine in NREM sleep, may ultimately open the possibility of inducing a synthetic torpor-like state in humans for medical applications and long-term space travel. To achieve this goal, it will be important, in perspective, to extend the study to other hypometabolic states, which, unlike torpor, can also be experienced by humans.Keywords
Funding Information
- National Institutes of Health: Heart and Lung (1R15HL120072-01A1)
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