Changing disease burden of hepatocellular carcinoma in the Far East and Southeast Asia
- 5 July 2005
- journal article
- review article
- Published by Wiley in Liver International
- Vol. 25 (4), 696-703
- https://doi.org/10.1111/j.1478-3231.2005.01139.x
Abstract
Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world, and has a marked difference in geographic distribution. More than 80% of HCC cases occur in developing countries, especially the Far East and Southeast Asia. Although immunization has been successful against hepatitis B virus (HBV), a changing disease burden of HCC has been observed in many parts of the world because of the increasing prevalence and duration of hepatitis C virus (HCV) infection in these countries. In addition, the age‐specific incidence of HCC has progressively shifted toward younger people. Hepatitis B genotypes B and C are prevalent in the Far East and Southeast Asia, and the clinical relevance of HBV genotypes has become increasingly recognized. Compared with genotype C, genotype B is associated with earlier hepatitis B e antigen seroconversion, slower progression to cirrhosis and less frequent development of HCC. By using periodic examinations of serum alfa‐fetoprotein levels and abdominal ultrasonography, small HCC can be detected and treated earlier. However, prevention of HBV and HCV infections as well as effective treatment of the chronic viral infections with timely interventions are still needed for the global control of HCC, particularly in the Far East and Southeast Asia.Keywords
This publication has 65 references indexed in Scilit:
- Long-term follow-up of alpha-interferon treatment of patients with chronic hepatitis BHepatology, 2004
- Interferon and prevention of hepatocellular carcinoma in viral cirrhosis: an evidence-based approachJournal of Hepatology, 2001
- Differences in survival based on the type of follow-up for the detection of hepatocellular carcinoma: an analysis of 547 patientsHepatology Research, 2000
- Global programme for control of hepatitis B infectionVaccine, 1995
- A clinicopathologic study of chronic non-A, non-B (type C) hepatitis in Taiwan: comparison between posttransfusion and sporadic patientsJournal of Hepatology, 1994
- Hepatocellular carcinomaJournal of Hepatology, 1992
- Hepatocellular carcinomaDigestive Diseases and Sciences, 1991
- Prevalence of antibody against the core protein of hepatitis C virus in patients with hepatocellular carcinomaInternational Journal of Cancer, 1991
- Prevalence of hepatitis C virus infection in Africa: Anti-HCV antibodies in the general population and in patients suffering from cirrhosis or primary liver cancerResearch in Virology, 1990
- Mass screening of primary hepatocellular carcinoma by alpha‐fetoprotein in a rural area of Taiwan – a dried blood spot methodLiver International, 1988