Recurrent Glomerulonephritis after Renal Transplantation
Open Access
- 1 May 2008
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Clinical Journal of the American Society of Nephrology
- Vol. 3 (3), 800-807
- https://doi.org/10.2215/cjn.04050907
Abstract
Background and objectives: Despite advances in prevention of acute rejection and improved short- and long-term kidney graft survival, recurrent glomerulonephritis remains problematic and poorly characterized. This study analyzed prevalence and outcome of recurrent glomerulonephritis from various registries. Design, setting, participants, & measurements: Definition, classification, and limitations in evaluating epidemiology of native and recurrent glomerulonephritis are discussed. Epidemiology of native glomerulonephritis as the cause of end-stage renal failure and subsequent recurrence of individual glomerulonephritis was evaluated using data from various registries, and pathogenesis of individual glomerulonephritis is discussed. Results: Analysis of data from transplant registries revealed that glomerulonephritis is an important cause of end-stage renal disease in white and pediatric recipients; however, glomerulonephritis as the cause of end-stage renal disease is not characterized well in black recipients, and many of them are perhaps labeled to have hypertensive nephrosclerosis as the cause of renal disease without renal biopsy. A systematic approach toward urinalysis after transplantation and utility of immunofluorescence and electron microscopic examination of renal biopsy tissues will identify the true prevalence of recurrent glomerulonephritis. Data on recurrent glomerulonephritis should be compiled by either using registry analysis or pooling data from multiple centers. This will provide true data on prevalence and outcome and could potentially initiate translational research studies. Conclusions: The understanding of the pathogenesis of recurrent glomerulonephritis is critical to optimize prevention as well as to treat individual recurrent glomerulonephritis, which can enhance long-term graft survival.This publication has 66 references indexed in Scilit:
- A classification of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura and related disordersKidney International, 2006
- Severity of primary MPGN, rather than MPGN type, determines renal survival and post-transplantation recurrence riskKidney International, 2006
- Recurrence of lupus nephritis after renal transplantation: if we look for it, will we find it?Nature Clinical Practice Nephrology, 2005
- Recurrence of Membranoproliferative Glomerulonephritis Type II in Renal AllograftsJournal of the American Society of Nephrology, 2005
- The risk of recurrence of hemolytic uremic syndrome after renal transplantation in childrenPediatric Nephrology, 2003
- Prediction and treatment of recurrent focal segmental glomerulosclerosis after renal transplantation in childrenAmerican Journal of Kidney Diseases, 1999
- Recurrence of glomerulonephritis following renal transplantationNephrology Dialysis Transplantation, 1999
- RECURRENCE OF TYPE I MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS AFTER RENAL TRANSPLANTATIONTransplantation, 1997
- INCIDENCE, TREATMENT, AND OUTCOME OF RECURRENT FOCAL SEGMENTAL GLOMERULOSCLEROSIS POSTTRANSPLANTATION IN 42 ALLOGRAFTS IN CHILDRENTransplantation, 1991
- THE RECURRENCE OF FOCAL SEGMENTAL GLOMERULOSCLEROSIS IN KIDNEY TRANSPLANT PATIENTS TREATED WITH CYCLOSPORINETransplantation, 1990