Safety and Efficacy Profile ofEchinacea purpureato Prevent Common Cold Episodes: A Randomized, Double-Blind, Placebo-Controlled Trial
Open Access
- 16 September 2012
- journal article
- research article
- Published by Hindawi Limited in Evidence-Based Complementary and Alternative Medicine
- Vol. 2012, 1-7
- https://doi.org/10.1155/2012/841315
Abstract
Objective. To investigate the safety (risk) and efficacy (benefit) ofEchinacea purpureaextract in the prevention of common cold episodes in a large population over a 4-month period.Methods. 755 healthy subjects were allocated to receive either an alcohol extract from freshly harvestedE. purpurea(95% herba and 5% root) or placebo. Participants were required to record adverse events and to rate cold-related issues in a diary throughout the investigation period. Nasal secretions were sampled at acute colds and screened for viruses.Results. A total of 293 adverse events occurred withEchinaceaand 306 with placebo treatment. Nine and 10% of participants experienced adverse events, which were at least possibly related to the study drug (adverse drug reactions). Thus, the safety ofEchinaceawas noninferior to placebo.Echinaceareduced the total number of cold episodes, cumulated episode days within the group, and pain-killer medicated episodes.Echinaceainhibited virally confirmed colds and especially prevented enveloped virus infections ().Echinaceashowed maximal effects on recurrent infections, and preventive effects increased with therapy compliance and adherence to the protocol.Conclusions. Compliant prophylactic intake ofE. purpureaover a 4-month period appeared to provide a positive risk to benefit ratio.
Keywords
This publication has 27 references indexed in Scilit:
- Anti-viral properties and mode of action of standardized Echinacea purpurea extract against highly pathogenic avian Influenza virus (H5N1, H7N7) and swine-origin H1N1 (S-OIV)Virology Journal, 2009
- Biology of Immune Responses to Vaccines in Elderly PersonsClinical Infectious Diseases, 2008
- Sufficiently Important Difference for Common Cold: Severity ReductionAnnals of Family Medicine, 2007
- An Evaluation ofEchinacea angustifoliain Experimental Rhinovirus InfectionsThe New England Journal of Medicine, 2005
- Treatment of the Common Cold with Echinacea: A Structured ReviewClinical Infectious Diseases, 2005
- Effectiveness of an Herbal Preparation Containing Echinacea, Propolis, and Vitamin C in Preventing Respiratory Tract Infections in ChildrenArchives of Pediatrics & Adolescent Medicine, 2004
- Medicinal properties of Echinacea: A critical reviewPhytomedicine, 2003
- The aging of the immune systemAdvances in Immunology, 2002
- Echinacea Root Extracts for the Prevention of Upper Respiratory Tract Infections: A Double-blind, Placebo-Controlled Randomized TrialArchives of Family Medicine, 1998
- Over-the-counter cold medications. A critical review of clinical trials between 1950 and 1991JAMA, 1993