No Evidence of Thyrotropin Receptor and GSα Gene Mutation in High Iodine Uptake Thyroid Carcinoma

Abstract

Usually, thyroid carcinoma presents as a cold nodule on radioiodine scintigraphy. High-uptake nodules on iodine thyroid scans are associated with an exceedingly low incidence of malignancy. Only 29 cases of carcinomas appearing as hot or warm nodules have as yet been reported. From 1993 to 1999, we have observed eight similar cases (4 hot and 4 warm thyroid nodules) suggesting that thyroid carcinomas may not be as rare as usually considered in these circumstances. Four tumors were available for molecular analysis on paraffin-embedded sections. Because no mutations were found in the whole coding portions of thyrotropin-receptor (TSHR) gene and fragments encompassing the mutational hot spots of the Gsα gene, it is unlikely that activating mutations of the TSH-R or G_sα genes were involved in these carcinomas.