Neural correlates of cognitive control of reaching movements in the dorsal premotor cortex of rhesus monkeys
Open Access
- 1 September 2011
- journal article
- research article
- Published by American Physiological Society in Journal of Neurophysiology
- Vol. 106 (3), 1454-1466
- https://doi.org/10.1152/jn.00995.2010
Abstract
Canceling a pending movement is a hallmark of voluntary behavioral control because it allows us to quickly adapt to unattended changes either in the external environment or in our thoughts. The countermanding paradigm allows the study of inhibitory processes of motor acts by requiring the subject to withhold planned movements in response to an infrequent stop-signal. At present the neural processes underlying the inhibitory control of arm movements are mostly unknown. We recorded the activity of single units in the rostral and caudal portion of the dorsal premotor cortex (PMd) of monkeys trained in a countermanding reaching task. We found that among neurons with a movement-preparatory activity, about one-third exhibit a modulation before the behavioral estimate of the time it takes to cancel a planned movement. Hence these neurons exhibit a pattern of activity suggesting that PMd plays a critical role in the brain networks involved in the control of arm movement initiation and suppression.Keywords
This publication has 78 references indexed in Scilit:
- Supplementary Motor Area Exerts Proactive and Reactive Control of Arm MovementsJournal of Neuroscience, 2010
- Roles of Monkey Premotor Neuron Classes in Movement Preparation and ExecutionJournal of Neurophysiology, 2010
- A Relative Position Code for Saccades in Dorsal Premotor CortexJournal of Neuroscience, 2010
- Functional Distinction Between Visuomovement and Movement Neurons in Macaque Frontal Eye Field During Saccade CountermandingJournal of Neurophysiology, 2009
- Intracranial EEG Reveals a Time- and Frequency-Specific Role for the Right Inferior Frontal Gyrus and Primary Motor Cortex in Stopping Initiated ResponsesJournal of Neuroscience, 2009
- Subcortical processes of motor response inhibition during a stop signal taskNeuroImage, 2008
- The role of the pre-supplementary motor area in the control of actionNeuroImage, 2007
- Dorsal Premotor Neurons Encode the Relative Position of the Hand, Eye, and Goal during Reach PlanningNeuron, 2006
- Differential Involvement of Neurons in the Dorsal and Ventral Premotor Cortex During Processing of Visual Signals for Action PlanningJournal of Neurophysiology, 2006
- Motor Cortical Activity during Interception of Moving Targets.Journal of Cognitive Neuroscience, 2001