A double‐blind randomized‐controlled trial comparing the desensitizing efficacy of a new dentifrice containing carbonate/hydroxyapatite nanocrystals and a sodium fluoride/potassium nitrate dentifrice
- 14 May 2010
- journal article
- research article
- Published by Wiley in Journal of Clinical Periodontology
- Vol. 37 (6), 510-517
- https://doi.org/10.1111/j.1600-051x.2010.01558.x
Abstract
Background and Aim: Several dentifrices have shown to be effective in reducing dentine hypersensitivity (DH), but more effective products are needed. The aim of the study was to evaluate the desensitizing efficacy of a new dentifrice based on zinc-carbonate hydroxyapatite (CHA) nanocrystals. Methods and Materials: Using a double-blind, randomized design, the new dentifrice was compared with potassium nitrate/fluoride dentifrice (active control). The participant's DH was evaluated at baseline and after 4 and 8 weeks using airblast (primary outcome), tactile, cold water and subjective tests (secondary outcomes). Results: The final sample consisted of 70 subjects with baseline DH; 36 received the new dentifrice and 34 the control one. Both dentifrices were largely effective; the percentage of score reduction from baseline to 8 weeks was greater than 28% for all tests (and greater than 55% for the cold water test) in both groups. As compared with controls, experimental subjects had a significantly greater improvement in the airblast test score (mean percentage of reduction of 46.0% versus 29.4% in controls) and the subjective test score (47.5% versus 28.1%, respectively), with both differences already being significant after 4 weeks. In contrast, there was no significant difference between groups for either the tactile or cold water tests at any time point and with any outcome. Conclusions: This study documented that the new dentifrice containing zinc-CHA nanocrystals significantly reduced dentinal hypersensitivity after 4 and 8 weeks, supporting its utility in clinical practiceKeywords
This publication has 35 references indexed in Scilit:
- Assessing fluoride treatment and resistance of dental enamel to soft drink erosion in vitro: Applications of focus variation 3D scanning microscopy and stylus profilometryJournal of Dentistry, 2009
- Non-inferiority trials are unethical because they disregard patients' interestsThe Lancet, 2007
- The Remineralizing Effect of Carbonate-Hydroxyapatite Nanocrystals on DentineMaterials Science Forum, 2007
- Dentine hypersensitivity: is there both stimulus and placebo responses in clinical trials?International Journal of Dental Hygiene, 2007
- Effect of stannous fluoride toothpaste on erosion‐like lesions: an in vivo studyEuropean Journal of Oral Sciences, 2006
- 2% Sodium Fluoride‐Iontophoresis Compared to a Commercially Available Desensitizing AgentThe Journal of Periodontology, 2005
- A cross‐sectional study of buccal cervical sensitivity in UK general dental practice and a summary review of prevalence studiesInternational Journal of Dental Hygiene, 2004
- Efficacy of a 3% Potassium Nitrate Desensitizing Mouthwash in the Treatment of Dentinal HypersensitivityThe Journal of Periodontology, 2001
- Comparative investigations of the desensitising efficacy of a new dentifriceJournal of Clinical Periodontology, 2001
- Clinical evaluation of a potassium nitrate dentifrice for the treatment of dentinal hypersensitivityJournal of Clinical Periodontology, 1994