Obesity and asthma: lessons from animal models
Open Access
- 1 February 2007
- journal article
- review article
- Published by American Physiological Society in Journal of Applied Physiology
- Vol. 102 (2), 516-528
- https://doi.org/10.1152/japplphysiol.00847.2006
Abstract
Epidemiological data indicate that obesity is a risk factor for asthma. These data are supported by observations in several murine models of obesity. Ob/ob, db/db, and Cpefatmice each exhibit innate airway hyperresponsiveness, a characteristic feature of asthma. These mice also respond more vigorously to common asthma triggers, including ozone. Here we discuss the implications of these data with respect to several mechanisms proposed to explain the relationship between obesity and asthma: 1) common etiologies; 2) comorbidities; 3) mechanical factors; and 4) adipokines. We focus on the role of adipokines, especially TNF-α, IL-6, leptin, and adiponectin. Understanding the mechanistic basis for the relationship between obesity and asthma may lead to novel therapeutic strategies for treatment of the obese asthmatic subject.Keywords
This publication has 100 references indexed in Scilit:
- Increased pulmonary responses to acute ozone exposure in obese db/db miceAmerican Journal of Physiology-Lung Cellular and Molecular Physiology, 2006
- Reactive oxygen species have a causal role in multiple forms of insulin resistanceNature, 2006
- Biomarkers and potential mechanisms of obesity-induced oxidant stress in humansInternational Journal of Obesity, 2005
- Obesity: insight into the origins of asthmaNature Immunology, 2005
- Adiponectin differentially regulates cytokines in porcine macrophagesBiochemical and Biophysical Research Communications, 2004
- Frozen objects: Small airways, big breaths, and asthmaJournal of Allergy and Clinical Immunology, 2000
- INFLAMMATORY AND ANTIOXIDANT GENE EXPRESSION IN C57BL/6J MICE AFTER LETHAL AND SUBLETHAL OZONE EXPOSURESExperimental Lung Research, 1999
- Detection and Quantification of the Leptin Receptor Splice Variants Ob-Ra, b, and, e in Different Mouse TissuesBiochemical and Biophysical Research Communications, 1997
- Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activityNature Genetics, 1995
- Ozone uptake in awake Sprague-Dawley ratsToxicology and Applied Pharmacology, 1987