Genotoxicity testing of the herbicide trifluralin and its commercial formulation Treflan using the piscine micronucleus test
- 30 April 2008
- journal article
- research article
- Published by Wiley in Environmental and Molecular Mutagenesis
- Vol. 49 (6), 434-438
- https://doi.org/10.1002/em.20401
Abstract
In this study, the genotoxic effects of a widely used herbicide, trifluralin, and its commercial formulation, Treflan, were evaluated using the micronucleus test in a commercially important fish species, Oreochromis niloticus (Nile Tilapia). Fish were exposed to 1, 5, and 10 μg/L doses of trifluralin and Treflan for 3, 6, and 9 days under laboratory conditions. Ethylmethanesulfonate, at a single dose of 10 mg/L, was used as positive control. Micronuclei were evaluated on the peripheral erythrocytes. Both Treflan and trifluralin treatments significantly increased the micronucleus frequencies in peripheral erythrocytes of O. niloticus. Furthermore, the genotoxicity of the active ingredient, trifluralin, was observed to be higher than that of the commercial formulation Treflan. Our results indicate that herbicide trifluralin has genotoxic potential in fish. Environ. Mol. Mutagen., 2008.Keywords
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