DNA Methylation in Mammals
Open Access
- 1 May 2014
- journal article
- review article
- Published by Cold Spring Harbor Laboratory in Cold Spring Harbor Perspectives in Biology
- Vol. 6 (5), a019133
- https://doi.org/10.1101/cshperspect.a019133
Abstract
DNA methylation is one of the best characterized epigenetic modifications. In mammals it is involved in various biological processes including the silencing of transposable elements, regulation of gene expression, genomic imprinting, and X-chromosome inactivation. This article describes how DNA methylation serves as a cellular memory system and how it is dynamically regulated through the action of the DNA methyltransferase (DNMT) and ten eleven translocation (TET) enzymes. Its role in the regulation of gene expression, through its interplay with histone modifications, is also described, and its implication in human diseases discussed. The exciting areas of investigation that will likely become the focus of research in the coming years are outlined in the summary.Keywords
This publication has 100 references indexed in Scilit:
- CpG Islands Recruit a Histone H3 Lysine 36 DemethylaseMolecular Cell, 2010
- DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activityThe EMBO Journal, 2008
- The Colorful History of Active DNA DemethylationCell, 2008
- Lineage-Specific Polycomb Targets and De Novo DNA Methylation Define Restriction and Potential of Neuronal ProgenitorsMolecular Cell, 2008
- A Chromatin Landmark and Transcription Initiation at Most Promoters in Human CellsCell, 2007
- Role for DNA methylation in genomic imprintingNature, 1993
- Targeted mutation of the DNA methyltransferase gene results in embryonic lethalityCell, 1992
- DNA methylation inhibits transcription indirectly via a methyl-CpG binding proteinCell, 1991
- Identification of a mammalian protein that binds specifically to DNA containing methylated CpGsCell, 1989
- A fraction of the mouse genome that is derived from islands of nonmethylated, CpG-rich DNACell, 1985