Gut hormones and the regulation of energy homeostasis
- 13 December 2006
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 444 (7121), 854-859
- https://doi.org/10.1038/nature05484
Abstract
Food intake, energy expenditure and body adiposity are homeostatically regulated. Central and peripheral signals communicate information about the current state of energy balance to key brain regions, including the hypothalamus and brainstem. Hunger and satiety represent coordinated responses to these signals, which include neural and hormonal messages from the gut. In recent years our understanding of how neural and hormonal brain–gut signalling regulates energy homeostasis has advanced considerably. Gut hormones have various physiological functions that include specifically targeting the brain to regulate appetite. New research suggests that gut hormones can be used to specifically regulate energy homeostasis in humans, and offer a target for anti-obesity drugs.This publication has 90 references indexed in Scilit:
- Vaccination against weight gainProceedings of the National Academy of Sciences of the United States of America, 2006
- Ghrelin action in the brain controls adipocyte metabolismJCI Insight, 2006
- The inhibitory effects of peripheral administration of peptide YY3–36 and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal–brainstem–hypothalamic pathwayBrain Research, 2005
- Blockade of the neuropeptide Y Y2 receptor with the specific antagonist BIIE0246 attenuates the effect of endogenous and exogenous peptide YY(3–36) on food intakeBrain Research, 2005
- Anatomy and regulation of the central melanocortin systemNature Neuroscience, 2005
- Adjunctive Therapy with Pramlintide Lowers HbA1c without Concomitant Weight Gain and Increased Risk of Severe Hypoglycemia in Patients with Type 1 Diabetes Approaching Glycemic TargetsExperimental and Clinical Endocrinology & Diabetes, 2005
- Monogenic Obesity in HumansAnnual Review of Medicine, 2005
- Enhancement of feeding suppression by PYY3-36 in rats with area postrema ablationsPeptides, 2004
- Inhibition of Food Intake in Obese Subjects by Peptide YY3–36The New England Journal of Medicine, 2003
- Neuropeptide Y and Peptide YY Inhibit Excitatory Synaptic Transmission in the Rat Dorsal Motor Nucleus of the VagusJournal Of Physiology-London, 2003