DNA Diagnostics—Molecular Techniques and Automation
- 14 October 1988
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 242 (4876), 229-237
- https://doi.org/10.1126/science.3051381
Abstract
Molecular biology has revolutionized the understanding of many aspects of human disease. Ongoing developments in DNA diagnostics--the analysis of disease at the nucleic acid level--will soon provide automated, rapid, and inexpensive analyses for DNA or RNA sequences associated with genetic, malignant, and infectious diseases. DNA diagnostics will also facilitate the identification of disease-associated genes at birth, thus creating new opportunities for preventive medicine.This publication has 140 references indexed in Scilit:
- Predictive Testing for Huntingtons Disease with Use of a Linked DNA MarkerThe New England Journal of Medicine, 1988
- Transmission of Human Immunodeficiency Virus (HIV) by Blood Transfusions Screened as Negative for HIV AntibodyThe New England Journal of Medicine, 1988
- Comparison and optimization of in situ hybridization procedures yielding rapid, sensitive mRNA detectionsGene Analysis Techniques, 1987
- Parallel free-text search on the connection machine systemCommunications of the ACM, 1986
- The human apolipoprotein B-100 gene: A highly polymorphic gene that maps to the short arm of chromosome 2Biochemical and Biophysical Research Communications, 1985
- Parvovirus InfectionThe New England Journal of Medicine, 1985
- Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresisCell, 1984
- Automatic DNA sequencer: Computer-programmed microchemical manipulator for the Maxam–Gilbert sequencing methodReview of Scientific Instruments, 1983
- Detection of specific sequences among DNA fragments separated by gel electrophoresisJournal of Molecular Biology, 1975
- Mutation and Cancer: Statistical Study of RetinoblastomaProceedings of the National Academy of Sciences of the United States of America, 1971