Maternal Smoking During Pregnancy and Offspring Conduct Problems
- 1 September 2013
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA Psychiatry
- Vol. 70 (9), 956-63
- https://doi.org/10.1001/jamapsychiatry.2013.127
Abstract
Several studies report an association between maternal smoking during pregnancy and offspring conduct disorder. However, past research evidences difficulty in disaggregating prenatal environmental influences from genetic and postnatal environmental influences. To examine the relationship between maternal smoking during pregnancy and offspring conduct problems among children reared by genetically related mothers and genetically unrelated mothers. The following 3 studies using distinct but complementary research designs were used: The Christchurch Health and Development Study (a longitudinal cohort study that includes biological and adopted children), the Early Growth and Development Study (a longitudinal adoption-at-birth study), and the Cardiff IVF (In Vitro Fertilization) Study (an adoption-at-conception study among genetically related families and genetically unrelated families). Maternal smoking during pregnancy was measured as the mean number of cigarettes per day (0, 1-9, or 10) smoked during pregnancy. Possible covariates were controlled for in the analyses, including child sex, birth weight, race/ethnicity, placement age, and breastfeeding, as well as maternal education and maternal age at birth and family breakdown, parenting practices, and family socioeconomic status. Offspring conduct problems (age range, 4-10 years) reported by parents or teachers using the behavior rating scales by Rutter and Conners, the Child Behavior Checklist and the Children's Behavior Questionnaire Short Form, and the Strengths and Difficulties Questionnaire. A significant association between maternal smoking during pregnancy and offspring conduct problems was observed among children reared by genetically related mothers and genetically unrelated mothers. Results from a meta-analysis affirmed this pattern of findings across pooled study samples. Findings across 3 studies using a complement of genetically sensitive research designs suggest that smoking during pregnancy is a prenatal risk factor for offspring conduct problems when controlling for specific perinatal and postnatal confounding factors.Keywords
This publication has 55 references indexed in Scilit:
- Do prenatal risk factors cause psychiatric disorder? Be wary of causal claimsThe British Journal of Psychiatry, 2009
- Maternal Smoking During Pregnancy and Child Outcomes: Real or Spurious Effect?Developmental Neuropsychology, 2009
- Maternal smoking during pregnancy and child behaviour problems: the Generation R StudyInternational Journal of Epidemiology, 2008
- The relationship of maternal smoking to psychological problems in the offspringEarly Human Development, 2007
- Maternal Cigarette Smoking during Pregnancy and Child Aggressive BehaviorThe American Journal on Addictions, 2006
- Neonatal nicotine exposure impairs nicotinic enhancement of central auditory processing and auditory learning in adult ratsEuropean Journal of Neuroscience, 2006
- Time trends in adolescent mental healthJournal of Child Psychology and Psychiatry, 2004
- Relationship of Maternal Smoking During Pregnancy With Criminal Arrest and Hospitalization for Substance Abuse in Male and Female Adult OffspringAmerican Journal of Psychiatry, 2002
- The Strengths and Difficulties Questionnaire: A Research NoteJournal of Child Psychology and Psychiatry, 1997
- Fetal nicotine exposure ablates the ability of postnatal nicotine challenge to release norepinephrine from rat brain regionsDevelopmental Brain Research, 1992