Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo
- 15 September 2006
- journal article
- Published by American Society of Hematology in Blood
- Vol. 108 (6), 2041-2044
- https://doi.org/10.1182/blood-2006-01-013490
Abstract
Somatic activation of a conditional targeted KrasG12D allele induces a fatal myeloproliferative disease in mice that closely models juvenile and chronic myelomonocytic leukemia. These mice consistently develop severe and progressive anemia despite adequate numbers of clonogenic erythroid progenitors in the bone marrow and expanded splenic hematopoiesis. Ineffective erythropoiesis is characterized by impaired differentiation. These results demonstrate that endogenous levels of oncogenic Ras have cell lineage-specific effects and support efforts to modulate Ras signaling for therapy of anemia in patients with myelodysplastic syndromes and myeloproliferative disorders.Keywords
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