Gymnastatins and Dankastatins, Growth Inhibitory Metabolites of a Gymnascella Species from a Halichondria Sponge
- 20 February 2008
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 71 (3), 340-345
- https://doi.org/10.1021/np070529a
Abstract
Four new metabolites, gymnastatins Q ( 3) and R ( 4) and dankastatins A ( 5) and B ( 6), have been isolated from the mycelial MeOH extract of a fungal strain of Gymnascella dankaliensis separated from a Halichondria sponge. Their stereostructures have been established on the basis of spectroscopic analysis using 1D and 2D NMR techniques. All of the isolated metabolites ( 3- 6) exhibited growth inhibition against the P388 cancer cell line. Furthermore, gymnastatin Q ( 3) showed appreciable growth inhibition against BSY-1 (breast) and MKN7 (stomach) human cancer cell lines.Keywords
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