Microcrystalline Cellulose in Tableting
- 1 May 1966
- journal article
- research article
- Published by Elsevier BV in Journal of Pharmaceutical Sciences
- Vol. 55 (5), 510-514
- https://doi.org/10.1002/jps.2600550513
Abstract
The development of microcrystalline cellulose has made available to the pharmaceutical industry an extremely valuable tableting agent. It was found that tablets of plain microcrystalline cellulose will tend to soften and swell when exposed to humid conditions, but the effect is reversed upon the removal of increased humidities. Elevated temperatures have no effect on these tablets. Microcrystalline cellulose tablets will disintegrate very slowly in solvents of a relatively low polarity. It is postulated that tablets of this material are a special form of cellulose fibril in which the individual crystallites are held together largely by hydrogen bonding. Tablet disintegration is merely the breaking of the intercrystallite bonds by the disintegrating medium. No significant separation of components was found during the compression of a microcrystalline cellulose-containing formulation. The release of amphetamine sulfate and sodium phenobarbital from tablets containing micro-crystalline cellulose is excellent. Determinations after 10 weeks at various environments indicate that no release problems exist. When the cellulosic compound was used as a dry binder—disintegrator in the direct compression of formulations of ephedrine hydrochloride, quinine sulfate, and a low melting steroid, tablets of outstanding quality were produced.Keywords
This publication has 8 references indexed in Scilit:
- Comparative Evaluation of Dextrose and Spray-Dried Lactose in Direct Compression SystemsJournal of Pharmaceutical Sciences, 1965
- Effect of Water Vapor Pressure on Moisture Sorption and the Stability of Aspirin and Ascorbic Acid in Tablet MatricesJournal of Pharmaceutical Sciences, 1965
- Preparation and Stability of Glyceryl Trinitrate Sublingual Tablets Prepared by Direct CompressionJournal of Pharmaceutical Sciences, 1965
- Effects of Concentration, Aging, and Temperature on Tablet Disintegrants in a Soluble Direct-Compression SystemJournal of Pharmaceutical Sciences, 1965
- Browning of Spray-Processed LactoseJournal of Pharmaceutical Sciences, 1964
- Comparative Evaluation of Tablet Formulations Prepared from Conventionally-Processed and Spray-Dried LactoseJournal of Pharmaceutical Sciences, 1963
- MICROCRYSTALLINE CELLULOSEIndustrial & Engineering Chemistry, 1962
- Discoloration of Tablets Containing Amines and LactoseJournal of Pharmaceutical Sciences, 1962