Prevalence of diphtheria and tetanus antibodies and circulation of Corynebacterium diphtheriae in São Paulo, Brazil.
Open Access
- 29 October 2007
- journal article
- Published by FapUNIFESP (SciELO) in Brazilian Journal of Medical and Biological Research
- Vol. 40 (12), 1681-1687
- https://doi.org/10.1590/s0100-879x2006005000184
Abstract
The introduction of routine vaccination against tetanus and diphtheria in Brazil has decreased the incidence and changed the epidemiology of both diseases. We then investigated the prevalence of Corynebacterium diphtheriae carrier status and diphtheria and tetanus immunity in São Paulo, Brazil. From November 2001 to March 2003, 374 individuals were tested for the presence of C. diphtheriae in the naso-oropharynx and of serum diphtheria and tetanus antibodies. Participants were all healthy individuals without acute or chronic pathologies and they were stratified by age as follows: 0-12 months and 1-4, 5-9, 10-14, 15-24, 25-39, 40-59, and > or =60 years. Antibodies were assessed using a double-antigen ELISA. C. diphtheriae species were identified by biochemical analysis and toxigenicity was assessed by the Elek test. For diphtheria, full protection (antibodies > or =0.1 IU/mL) was present in 84% of the individuals, 15% had basic protection (antibodies > or =0.01 and or =0.1 IU/mL) was present in 79% of the participants, 18% had basic protection (antibodies > or =0.01 and <0.1 IU/mL) and 3% were susceptible (antibodies <0.01 IU/mL). The geometric mean of diphtheria and tetanus antibodies reached the highest values at 5-9 years and decreased until the 40-59-year age range, increasing again in individuals over 60 years. Three participants (0.8%) were carriers of C. diphtheriae, all non-toxigenic strains. The present results demonstrate the clear need of periodic booster for tetanus and diphtheria vaccine in adolescents and adults after primary immunization in childhood.Keywords
This publication has 14 references indexed in Scilit:
- Tetanus and diphtheria immunity in adolescents from São Paulo, BrazilBrazilian Journal of Medical and Biological Research, 2007
- Compliance with recommended immunizations in adolescentsEuropean Journal of Pediatrics, 2006
- Effect of a single tetanus-diphtheria vaccine dose on the immunity of elderly people in São Paulo, BrazilBrazilian Journal of Medical and Biological Research, 2006
- Human Clinical Isolates of Corynebacterium diphtheriae and Corynebacterium ulcerans Collected in Canada from 1999 to 2003 but Not Fitting Reporting Criteria for Cases of DiphtheriaJournal of Clinical Microbiology, 2005
- Tetanus and diphtheria antibodies and response to a booster dose in Brazilian HIV-1-infected womenVaccine, 2004
- Immunity to diphtheria and tetanus in England and WalesVaccine, 2000
- The Changing Epidemiology of Diphtheria in the Vaccine EraThe Journal of Infectious Diseases, 2000
- Successful Control of Epidemic Diphtheria in the States of the Former Union of Soviet Socialist Republics: Lessons LearnedThe Journal of Infectious Diseases, 2000
- Epidemic Diphtheria in the Republic of Georgia, 1993–1996: Risk Factors for Fatal Outcome among Hospitalized PatientsThe Journal of Infectious Diseases, 2000
- Improved ELISA for determination of anti‐diphtheria and/or anti‐tetanus antitoxin antibodies in seraAPMIS, 1997