CXCR4 Expression in Prostate Cancer Progenitor Cells
Open Access
- 16 February 2012
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 7 (2), e31226
- https://doi.org/10.1371/journal.pone.0031226
Abstract
Tumor progenitor cells represent a population of drug-resistant cells that can survive conventional chemotherapy and lead to tumor relapse. However, little is known of the role of tumor progenitors in prostate cancer metastasis. The studies reported herein show that the CXCR4/CXCL12 axis, a key regulator of tumor dissemination, plays a role in the maintenance of prostate cancer stem-like cells. The CXCL4/CXCR12 pathway is activated in the CD44+/CD133+ prostate progenitor population and affects differentiation potential, cell adhesion, clonal growth and tumorigenicity. Furthermore, prostate tumor xenograft studies in mice showed that a combination of the CXCR4 receptor antagonist AMD3100, which targets prostate cancer stem-like cells, and the conventional chemotherapeutic drug Taxotere, which targets the bulk tumor, is significantly more effective in eradicating tumors as compared to monotherapy.Keywords
This publication has 46 references indexed in Scilit:
- Identification of a Cell of Origin for Human Prostate CancerScience, 2010
- Dynamic regulation of ROCK in tumor cells controls CXCR4-driven adhesion eventsJournal of Cell Science, 2010
- Basal epithelial stem cells are efficient targets for prostate cancer initiationProceedings of the National Academy of Sciences of the United States of America, 2010
- Multiple Lineages of Human Breast Cancer Stem/Progenitor Cells Identified by Profiling with Stem Cell MarkersPLOS ONE, 2009
- Lin−Sca-1+CD49fhigh Stem/Progenitors Are Tumor-Initiating Cells in the Pten-Null Prostate Cancer ModelCancer Research, 2009
- CXCL12 increases human neural progenitor cell proliferation through Akt‐1/FOXO3a signaling pathwayJournal of Neurochemistry, 2009
- CXCR4 mediates the proliferation of glioblastoma progenitor cellsCancer Letters, 2009
- The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populationsProceedings of the National Academy of Sciences of the United States of America, 2009
- The Role of CD133 in Normal Human Prostate Stem Cells and Malignant Cancer-Initiating CellsCancer Research, 2008
- A FoxO–Smad synexpression group in human keratinocytesProceedings of the National Academy of Sciences of the United States of America, 2006