Montelukast as an adjuvant to mainstay therapies in patients with seasonal allergic rhinitis
- 10 June 2003
- journal article
- clinical trial
- Published by Wiley in Clinical and Experimental Allergy
- Vol. 33 (6), 823-826
- https://doi.org/10.1046/j.1365-2222.2003.01690.x
Abstract
Drug selection for optimal treatment of allergic rhinitis may be difficult and involve many diverse factors. To evaluate montelukast, in the treatment of patients with seasonal allergic rhinitis, as an adjuvant to mainstay therapies, i.e., antihistamines and corticosteroids. The study was a prospective, three-phased (per lasted 2 weeks) clinical trial. In phase I, patients were separated into two groups, based on the predominating symptoms: (1) runners (patients with moderate to severe sneezing/itchy, watery nose/itchy, watery eyes), and (2) blockers (patients with moderate to severe nasal congestion). The runners received antihistamine loratidine 10 mg daily, and the blockers received intranasal corticosteroid mometasone furoate 200 microg. In phase II, if patients were dissatisfied with the initial treatment, they were assigned to receive another study drug additionally. In phase III, for the patients unsatisfied with the treatment of loratidine plus mometasone furoate, montelukast 10 mg once daily was added. Of the 169 patients who entered phase I, 150 could be evaluated for treatment efficacy and safety. There were 108 runners and 42 blockers. Physicians' and patients' assessments indicated that in phase I 58 runners (60.0% of 50 runners) and 36 blockers (33.3% of six blockers) were satisfied with their therapy. In phase II, 30 runners (27.7%) and two blockers (4.7%) were satisfied with the addition of other study drug. Totally 62.6% of patients were satisfied at the end of phase I, and 84.0% at the end of phase II. Sixteen patients (66.6% of 24 patients) were satisfied with the addition of montelukast to the previous two drugs (in total, 10.6% of patients). Fourteen patients (12.2%) treated with loratadine, and three patients (0.3%) treated with mometasone, reported side-effect. The results of this trial indicate that 10% of patients with seasonal allergic rhinitis may be treated with the supplement of montelukast to mainstay therapy.Keywords
This publication has 10 references indexed in Scilit:
- Comparison of the efficacy, safety and quality of life provided by fexofenadine hydrochloride 120 mg, loratadine 10 mg and placebo administered once daily for the treatment of seasonal allergic rhinitisClinical and Experimental Allergy, 2000
- Concomitant montelukast and loratadine as treatment for seasonal allergic rhinitis: A randomized, placebo-controlled clinical trialJournal of Allergy and Clinical Immunology, 2000
- Consensus statement * on the treatment of allergic rhinitisAllergy, 2000
- Randomized Placebo-controlled Study Comparing a Leukotriene Receptor Antagonist and a Nasal Glucocorticoid in Seasonal Allergic RhinitisAmerican Journal of Respiratory and Critical Care Medicine, 1999
- The effects of salmeterol on power output in nonasthmatic athletes.Journal of Allergy and Clinical Immunology, 1997
- Model for outcomes assessment of antihistamine use for seasonal allergic rhinitisJournal of Allergy and Clinical Immunology, 1996
- The leukotriene D4-receptor antagonist, ICI 204,219, relieves symptoms of acute seasonal allergic rhinitis.American Journal of Respiratory and Critical Care Medicine, 1995
- Loratadine and terfenadine in perennial allergic rhinitis.Allergy, 1993
- Reduced Allergen-Induced Nasal Congestion and Leukotriene Synthesis with an Orally Active 5-Lipoxygenase InhibitorNew England Journal of Medicine, 1990
- The effect of a leukotriene antagonist on the early response to antigenOtolaryngology -- Head and Neck Surgery, 1990