Induction of Tolerance via the Respiratory Mucosa
- 1 June 1998
- journal article
- review article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 116 (2), 93-102
- https://doi.org/10.1159/000023931
Abstract
Immunological tolerance is defined as a state of specific non-responsiveness to a particular antigen induced by previous exposure to that same antigen. The mucosal surfaces comprise the upper and lower respiratory tracts, the gastrointestinal tract and the urogenitary tract, and are a major site of antigenic challenge. The immune system associated with the mucosa has the extraordinary potential to discriminate between antigens that are harmless (e.g. inhaled and dietary antigens) and those that are associated with pathogens. Normally soluble proteins delivered through the mucosal surfaces do not elicit a strong systemic immune response but instead induce a transient local immune response that is replaced by long-term peripheral unresponsiveness – this is termed mucosal tolerance. The phenomenon of oral tolerance is well established and considerable attention has focussed on defining the underlying mechanisms. However, only comparatively recently was the induction of tolerance via the respiratory mucosa described, and it is this form of mucosal tolerance which forms the basis of this review.Keywords
This publication has 18 references indexed in Scilit:
- CD8 T-Cells Are Not Essential for the Induction of “Low-Dose” Oral ToleranceClinical Immunology and Immunopathology, 1996
- The role of the T cell costimulator B7-1 in autoimmunity and the induction and maintenance of tolerance to peripheral antigenImmunity, 1994
- Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of AutoantigensAnnual Review of Immunology, 1994
- Lymphokine Production by Human T Cells in Disease StatesAnnual Review of Immunology, 1994
- Gamma/Delta T CellsAnnual Review of Immunology, 1993
- Functional subsets of allergen-reactive human CD4+ T cellsImmunology Today, 1991
- Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance inductionCell, 1991
- Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic miceCell, 1991
- Tolerance of class I histocompatibility antigens expressed extrathymicallyNature, 1989
- Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic culturesNature, 1989