Skin cancer in survivors of childhood and adolescent cancer
- 31 March 2006
- journal article
- Published by Elsevier BV in European Journal Of Cancer
- Vol. 42 (5), 656-659
- https://doi.org/10.1016/j.ejca.2005.08.042
Abstract
The incidence of basal cell carcinoma (BCC) has been related to ionizing radiation, particularly for exposure occurring at young age. In this study, we considered the incidence of second skin neoplasms in long-term survivors from childhood cancer. We considered second primary cancers occurring among 776 subjects (436 males, 340 females) with first primary cancer diagnosed before age 20 years, between 1974 and 2001, in the Swiss Cantons of Vaud and Neuchâtel (786,000 inhabitants). Five BCC were observed versus 0.43 expected (standardized incidence ratio: 11.6, 95% confidence interval: 3.7–27.1). No case of cutaneous squamous cell carcinoma, nor of malignant melanoma was observed. The estimated radiation doses at 1 mm through the skin ranged between 7 and 27 Sv. These data confirm that BCC are strongly related to ionizing radiation exposure in childhood. All the BCC were located within the radiation field, thus indicating that ionizing radiation is the key aetiological factor, even in the absence of any meaningful interaction with UV.Keywords
This publication has 9 references indexed in Scilit:
- Histologic characteristics of skin cancer in Hiroshima and Nagasaki: Background incidence and radiation effectsInternational Journal of Cancer, 2005
- Nonmelanoma skin cancer in relation to ionizing radiation exposure among U.S. radiologic technologistsInternational Journal of Cancer, 2005
- Therapeutic Ionizing Radiation and the Incidence of Basal Cell Carcinoma and Squamous Cell CarcinomaArchives of Dermatology, 2000
- Skin tumor risk among atomic-bomb survivors in JapanCancer Causes and Control, 1998
- Risk of Basal Cell and Squamous Cell Skin Cancers After Ionizing Radiation TherapyJNCI Journal of the National Cancer Institute, 1996
- Trends of skin cancer in the Canton of Vaud, 1976-92British Journal of Cancer, 1995
- A Measurement and Analysis of Buildup Region Dose for Open Field Photon Beams (Cobalt-60 through 24 MV)Medical Dosimetry, 1994
- Multiple primary cancers in the Vaud Cancer Registry, Switzerland, 1974-89British Journal of Cancer, 1993
- Buildup/surface dose and exit dose measurements for a 6-MV linear acceleratorMedical Physics, 1986