Social regulation of serotonin in the auditory midbrain.
- 1 January 2011
- journal article
- Published by American Psychological Association (APA) in Behavioral Neuroscience
- Vol. 125 (4), 501-511
- https://doi.org/10.1037/a0024426
Abstract
The neuromodulator serotonin regulates auditory processing and can increase within minutes in response to stimuli like broadband noise as well as nonauditory stressors. Little is known about the serotonergic response in the auditory system to more natural stimuli such as social interactions. Using carbon-fiber voltammetry, we measured extracellular serotonin in the auditory midbrain of resident male mice during encounters with a male intruder. Serotonin increased in the inferior colliculus (IC) over the course of a 15 minute interaction, but not when mice were separated with a perforated barrier. Several behaviors, including the amount of immobility and anogenital investigation performed by the resident, were correlated with the serotonergic response. Multiple intrinsic factors associated with individual mice also correlated with the serotonergic response. One of these was age: older mice had smaller serotonergic responses to the social interaction. In a second interaction, individual identity predicted serotonergic responses that were highly consistent with those in the first interaction, even when mice were paired with different intruders. Serotonin was also significantly elevated in the second social interaction relative to the first, suggesting a role for social experience. These findings show that during social interaction, serotonin in the IC is influenced by extrinsic factors such as the directness of social interaction and intrinsic factors including age, individual identity, and experience.Keywords
Funding Information
- National Institute on Deafness and Other Communication Disorders (DC-008963)
This publication has 69 references indexed in Scilit:
- Efficient Encoding of Vocalizations in the Auditory MidbrainJournal of Neuroscience, 2010
- Dissecting natural sensory plasticity: Hormones and experience in a maternal contextHearing Research, 2009
- Activation of serotonin 3 receptors changes in vivo auditory responses in the mouse inferior colliculusHearing Research, 2009
- Syllable acoustics, temporal patterns, and call composition vary with behavioral context in Mexican free-tailed batsThe Journal of the Acoustical Society of America, 2008
- Activation of the serotonin 1A receptor alters the temporal characteristics of auditory responses in the inferior colliculusBrain Research, 2007
- Individual Variation in Coping with Stress: A Multidimensional Approach of Ultimate and Proximate MechanismsBrain, Behavior and Evolution, 2007
- Topographic organization and neurochemical identity of dorsal raphe neurons that project to the trigeminal somatosensory pathway in the ratJournal of Comparative Neurology, 2001
- THEEVOLUTION OFCOLORVISION ININSECTSAnnual Review of Entomology, 2001
- Single unit response of noradrenergic, serotonergic and dopaminergic neurons in freely moving cats to simple sensory stimuliBrain Research, 1986
- Emotionality and Aggressive Behavior in the Mouse as a Function of Infantile ExperienceThe Journal of Genetic Psychology, 1959