Syntheses and Biological Evaluation of B-Ring-Modified Analogues of Dafachronic Acid A
- 19 July 2008
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 10 (16), 3643-3645
- https://doi.org/10.1021/ol801425v
Abstract
Synthesis and testing of dafachronic acid A (1) and its derivatives 2 and 3 have revealed that 1, and not a further oxidation product, is the natural ligand for the DAF-12 receptor of Caenorhabditis elegans.Keywords
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