Sibling rivalry in the E2F family
Top Cited Papers
- 1 January 2002
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Molecular Cell Biology
- Vol. 3 (1), 11-20
- https://doi.org/10.1038/nrm714
Abstract
The E2F transcription factor family determines whether or not a cell will divide by controlling the expression of key cell-cycle regulators. The individual E2Fs can be divided into distinct subgroups that act in direct opposition to one another to promote either cellular proliferation or cell-cycle exit and terminal differentiation. What is the underlying molecular basis of this 'push-me–pull-you' regulation, and what are its biological consequences?Keywords
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