Th17 Cells and Autoimmune Encephalomyelitis (EAE/MS)
Open Access
- 1 January 2008
- journal article
- review article
- Published by Japanese Society of Allergology in Allergology International
- Vol. 57 (2), 115-120
- https://doi.org/10.2332/allergolint.r-07-159
Abstract
Multiple sclerosis (MS) is a CD4+ T cell-mediated autoimmune disease affecting the central nervous system. It was largely accepted that Th1 cells driven by IL-12 were pathogenic T cells in human MS and experimental autoimmune encephalomyelitis, an animal model of MS. Recent data have established that IL-17-producing CD4+ T cells, driven by IL-23 and referred to as Th17 cells, play a pivotal role in the pathogenesis of EAE. A combination of TGF-p and IL-6 induce Th17 cell lineage commitment via expression of transcription factor RORyt. Th17 cells and induced Foxp3+ T regulatory cells are in reciprocal position in the T cell lineage commitment governed by TGF-p and IL-6. The vitamin A metabolite retinoic acid is involved in this process via TGF-p dependent induction of Foxp3. We have demonstrated that human Th17 cells could be identified as CCR2+ CCR5- memory CD4+ T cells. It is becoming clear that IL-23/Th17 axis also plays an important role in the pathogenesis of various human autoimmune diseases including MS. Additionally, accumulating evidences raise a possibility that CCR2 on Th17 cells may be a therapeutic target in MSKeywords
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