Adiponectin and Adiponectin Receptor Gene Variants in Relation to Type 2 Diabetes and Insulin Resistance-Related Phenotypes
- 1 January 2008
- journal article
- Published by JCFCorp SG PTE LTD in The Review of Diabetic Studies
- Vol. 5 (1), 28-37
- https://doi.org/10.1900/rds.2008.5.28
Abstract
Alterations in adiponectin-mediated pathways are known to be associated with glucose intolerance, insulin resistance (IR), obesity, and type 2 diabetes (T2D) mellitus. Genetic variations in adiponectin (ADIPOQ) and adiponectin 1 and 2 receptor (ADIPOR1 and ADIPOR2) could have effects on IR-related phenotypes and T2D. Here we examine whether the polymorphic markers rs2241766 (ADIPOQ), rs22753738 (ADIPOR1), rs11061971 and rs16928751 (both in ADIPOR2) are implicated in susceptibility to T2D in a Russian population. The polymorphic markers were genotyped in 129 T2D patients, and 117 non-diabetic controls, by polymerase chain reaction (PCR) restriction fragment length polymorphism approach. In the subjects, biochemical characteristics including serum insulin, plasma glucose and serum lipids/lipoproteins were measured and compared for correlation with the genetic variations studied. Allele T of rs11061971 and allele A of rs16928751 showed association with higher risk of diabetes providing odds ratios (OR) of 2.05 (p = 0.0025) and 1.88 (p = 0.018), respectively. Haplotype A-G consisting of allele A of rs11061971 and allele G of rs16928751 was associated with reduced risk of T2D (OR = 0.59, pc = 0.0224). Compared to other variants, diabetic patients double homozygous for A/A of rs16928751 and G/G of rs16928751 had decreased homeostasis model assessment-insulin resistance (pc = 0.0375) and serum triglycerides (pc = 0.0285). The variants of ADIPOR2 confer susceptibility to T2D and are associated with some IR-related phenotypes in the Russian study population.Keywords
This publication has 31 references indexed in Scilit:
- LDA—a java-based linkage disequilibrium analyzerBioinformatics, 2003
- Cloning of adiponectin receptors that mediate antidiabetic metabolic effectsNature, 2003
- Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinaseNature Medicine, 2002
- Increased Fat Intake, Impaired Fat Oxidation, and Failure of Fat Cell Proliferation Result in Ectopic Fat Storage, Insulin Resistance, and Type 2 Diabetes MellitusAnnals of the New York Academy of Sciences, 2002
- Endogenous glucose production is inhibited by the adipose-derived protein Acrp30JCI Insight, 2001
- Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic PatientsArteriosclerosis, Thrombosis, and Vascular Biology, 2000
- Statistics Notes: The odds ratioBMJ, 2000
- Decreased Expression Of apM1 in Omental and Subcutaneous Adipose Tissue of Humans With Type 2 DiabetesInternational Journal of Experimental Diabetes Research, 2000
- cDNA Cloning and Expression of a Novel Adipose Specific Collagen-like Factor, apM1 (AdiposeMost Abundant Gene Transcript 1)Biochemical and Biophysical Research Communications, 1996
- Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative UltracentrifugeClinical Chemistry, 1972