Cerebral Carbohydrate and Energy Metabolism in Perinatal Hypoxic-Ischemic Brain Damage
- 1 July 1992
- journal article
- Published by Wiley in Brain Pathology
- Vol. 2 (3), 229-234
- https://doi.org/10.1111/j.1750-3639.1992.tb00696.x
Abstract
Cerebral hypoxia-ischemia remains a major cause of acute perinatal brain injury. Research in experimental animals over the past decade has greatly expanded our knowledge of those oxidative events which occur during a hypoxic-ischemic insult to the brain, as well as those metabolic alterations which evolve during the recovery period following resuscitation. The available evidence suggests that hypoxia alone does not lead to brain damage, but rather a combination of hypoxia-ischemia or isolated cerebral ischemia is a necessary prerequisite for tissue injury to occur. Furthermore, hypoxia-ischemia severe enough to produce irreversible tissue injury is always associated with major perturbations in the energy status of the perinatal brain which persists well into the recovery period. The lingering energy depletion sets in motion a cascade of biochemical alterations that are initiated during the course of the insult and proceed well into the recovery period to culminate in either neuronal necrosis or infarction. Unlike the adult, where glucose supplementation prior to or during hypoxia-ischemia accentuates tissue injury, glucose treatment of perinatal animals subjected to a similar insult substantially reduces the extent of tissue injury. The mechanism for the age-specific effect of glucose on hypoxic-ischemic brain damage is discussed in relation to pathogenetic mechanisms responsible for the occurrence of permanent brain damage.Keywords
This publication has 33 references indexed in Scilit:
- Carbohydrate and Energy Metabolism during the Evolution of Hypoxic-Ischemic Brain Damage in the Immature RatJournal of Cerebral Blood Flow & Metabolism, 1990
- Hypoxic-ischemic cerebral necrosis in midgestational sheep fetuses: Physiopathologic correlationsExperimental Neurology, 1983
- Columnar Alterations of NADH Fluorescence during Hypoxia-Ischemia in Immature Rat BrainJournal of Cerebral Blood Flow & Metabolism, 1982
- Deleterious effect of glucose pretreatment on recovery from diffuse cerebral ischemia in the cat. II. Regional metabolite levels.Stroke, 1980
- CEREBRAL BLOOD FLOW AND EXCHANGE OF OXYGEN, GLUCOSE KETONE BODIES, LACTATE, PYRUVATE AND AMINO ACIDS IN ANESTHETIZED CHILDRENActa Paediatrica, 1980
- Cerebral metabolism in newborn dogs during reversible asphyxiaAnnals of Neurology, 1977
- CARBOHYDRATE AND ENERGY METABOLISM IN PERINATAL RAT BRAIN: RELATION TO SURVIVAL IN ANOXIAJournal of Neurochemistry, 1975
- REMOVAL AND UTILIZATION OF KETONE BODIES BY THE BRAIN OF NEWBORN PUPPIESJournal of Neurochemistry, 1972
- Resuscitation by positive pressure ventilation and Tris-hydroxymethylaminomethane of rhesus monkeys asphyxiated at birthThe Journal of Pediatrics, 1964
- The effect of alkali and glucose infusion on permanent brain damage in rhesus monkeys asphyxiated at birthThe Journal of Pediatrics, 1964