Treatment of Latent Tuberculosis Infection in Patients Aged ≥35 Years
Open Access
- 1 September 2000
- journal article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 31 (3), 826-829
- https://doi.org/10.1086/314037
Abstract
Treating patients aged ≥35 years for tuberculosis infection has been controversial because of the hepatotoxic effects of isoniazid. A 2-year retrospective cohort study of outpatient medical records determined the completion rate in this age group and identified risk factors associated with isoniazid-associated hepatotoxicity. Isoniazid preventative therapy was well tolerated. However, toxicity occurred in women receiving concomitant medications and men who used alcohol.Keywords
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