Electrocardiographic Abnormalities in Trypanosoma cruzi Seropositive and Seronegative Former Blood Donors
Open Access
- 28 February 2013
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLoS Neglected Tropical Diseases
- Vol. 7 (2), e2078
- https://doi.org/10.1371/journal.pntd.0002078
Abstract
Blood donor screening leads to large numbers of new diagnoses of Trypanosoma cruzi infection, with most donors in the asymptomatic chronic indeterminate form. Information on electrocardiogram (ECG) findings in infected blood donors is lacking and may help in counseling and recognizing those with more severe disease. To assess the frequency of ECG abnormalities in T.cruzi seropositive relative to seronegative blood donors, and to recognize ECG abnormalities associated with left ventricular dysfunction. The study retrospectively enrolled 499 seropositive blood donors in São Paulo and Montes Claros, Brazil, and 483 seronegative control donors matched by site, gender, age, and year of blood donation. All subjects underwent a health clinical evaluation, ECG, and echocardiogram (Echo). ECG and Echo were reviewed blindly by centralized reading centers. Left ventricular (LV) dysfunction was defined as LV ejection fraction (EF)Trypanosoma cruzi, is endemic in most Latin America countries and may be transmitted via blood transfusions. Cardiac disease is a major feature of chronically infected patients and may be lethal. Universal blood bank screening for ChD has been established in most Latin American countries, as well as in non-endemic countries with large immigrant populations, including the United States, Canada, Spain and Portugal. Blood donor screening leads to large numbers of new diagnoses of chronic T. cruzi infection. Counseling these individuals should address the recognition of those with more severe disease that deserve to be rigorously evaluated by experienced cardiologists and treated more promptly. The electrocardiogram is an important exam that can help in the recognition of cardiac disease and the evaluation of prognosis in ChD patients, but its role in blood donors has not been studied. The authors describe some electrocardiographic abnormalities that are typical of the infected blood donors, as well ECG abnormalities that help in the identification of those with severe cardiac involvement. These results may guide the evaluations of patients with incidentally detected T. cruzi infection from blood bank testing or public health screening.Keywords
This publication has 46 references indexed in Scilit:
- Response to Letters Regarding Article, “Ten-Year Incidence of Chagas Cardiomyopathy Among Asymptomatic, Trypanosoma cruzi –Seropositive Former Blood Donors”Circulation, 2013
- Seroprevalence of Chagas Infection in the Donor PopulationPLoS Neglected Tropical Diseases, 2012
- Insights into the clinical and functional significance of cardiac autonomic dysfunction in Chagas diseaseRevista da Sociedade Brasileira de Medicina Tropical, 2012
- The prognostic significance of electrocardiographic changes in Chagas diseaseJournal of Electrocardiology, 2012
- Enhanced classification of Chagas serologic results and epidemiologic characteristics of seropositive donors at three large blood centers in BrazilTransfusion, 2010
- Brain natriuretic peptide based strategy to detect left ventricular dysfunction in Chagas disease: A comparison with the conventional approachInternational Journal of Cardiology, 2006
- Vagal dysfunction in Chagas diseaseInternational Journal of Cardiology, 2005
- Can cardiac vagal tone be estimated from the 10-second ECG?International Journal of Cardiology, 2004
- Electrocardiographic abnormalities and left ventricular systolic function in Chagas' heart diseaseInternational Journal of Cardiology, 1990
- Relationship of electrocardiographic abnormalities and seropositivity to Trypanosoma cruzi within a rural community in Northeast BrazilAmerican Heart Journal, 1983