Ferricrocin, a Siderophore Involved in Intra- and Transcellular Iron Distribution in Aspergillus fumigatus
- 15 June 2009
- journal article
- research article
- Published by American Society for Microbiology in Applied and Environmental Microbiology
- Vol. 75 (12), 4194-4196
- https://doi.org/10.1128/aem.00479-09
Abstract
Iron is an essential metal for virtually all organisms. Iron acquisition is well characterized for various organisms, whereas intracellular iron distribution is poorly understood. In contrast to bacteria, plants, and animals, most fungi lack ferritin-mediated iron storage but possess an intracellular siderophore shown to be involved in iron storage. Here we demonstrate that deficiency in the intracellular siderophore ferricrocin causes iron starvation in conidia of Aspergillus fumigatus , demonstrating that ferricrocin is also involved in intra- and transcellular iron distribution. Thus, ferricrocin represents the first intracellular iron transporter identified in any organism.Keywords
This publication has 17 references indexed in Scilit:
- SreA‐mediated iron regulation in Aspergillus fumigatusMolecular Microbiology, 2008
- A Cytosolic Iron Chaperone That Delivers Iron to FerritinScience, 2008
- Intracellular Siderophores Are Essential for Ascomycete Sexual Development in Heterothallic Cochliobolus heterostrophus and Homothallic Gibberella zeaeEukaryotic Cell, 2007
- Interaction of HapX with the CCAAT-binding complex—a novel mechanism of gene regulation by ironThe EMBO Journal, 2007
- NPS6, Encoding a Nonribosomal Peptide Synthetase Involved in Siderophore-Mediated Iron Metabolism, Is a Conserved Virulence Determinant of Plant Pathogenic AscomycetesPlant Cell, 2006
- Anemia of Chronic DiseaseNew England Journal of Medicine, 2005
- Siderophore Biosynthesis But Not Reductive Iron Assimilation Is Essential forAspergillus fumigatusVirulenceThe Journal of Experimental Medicine, 2004
- Bacterial iron homeostasisFEMS Microbiology Reviews, 2003
- SREA is involved in regulation of siderophore biosynthesis, utilization and uptake in Aspergillus nidulansMolecular Microbiology, 2001
- Ferricrocin functions as the main intracellular iron-storage compound in mycelia ofNeurospora crassaBioMetals, 1988