Remote ischemic precondition preserves cerebral oxygen tension during hypothermic circulatory arrest
- 6 March 2012
- journal article
- Published by Informa UK Limited in Scandinavian Cardiovascular Journal
- Vol. 46 (4), 245-250
- https://doi.org/10.3109/14017431.2012.661874
Abstract
Objectives. Remote ischemic preconditioning (RIPC) is a novel and promising method of mitigating neurological injury. In previous animal studies, RIPC has provided substantial neuroprotective effects. We hypothesized that the promising neuroprotective properties were a consequence of a better oxygen consumption profile during hypothermic circulatory arrest (HCA). Design. Six 7-week-old female pigs were randomly assigned to undergo the 60 minutes of HCA with the right hind leg receiving transient RIPC preoperatively and six animals were assigned to a control group that underwent 60 minutes of HCA without any preconditioning. A combined temperature/oxygen-tension probe was inserted into the parietal cortex of each animal to monitor cerebral oxygen tension during experiments. Results. The RIPC group had significantly higher cerebral oxygen tension readings throughout the HCA. Statistically significant differences were measured from the 20 minute time point onwards in every time point up to the 60 minute time point. Conclusions. This study shows that RIPC performed before HCA conserves the cerebral oxygen tension during a circulatory arrest. RIPC could possibly prolong the safe operating time during HCA as cerebral oxygen content is preserved throughout circulatory arrest.Keywords
This publication has 17 references indexed in Scilit:
- Outcomes after thoracoabdominal aortic aneurysm repair with hypothermic circulatory arrestThe Journal of Thoracic and Cardiovascular Surgery, 2011
- Remote Ischemic Preconditioning Protects the Brain Against Injury After Hypothermic Circulatory ArrestCirculation, 2011
- Improved Cerebral Recovery From Hypothermic Circulatory Arrest After Remote Ischemic PreconditioningThe Annals of Thoracic Surgery, 2010
- Mitochondrial mechanisms of cell death and neuroprotection in pediatric ischemic and traumatic brain injuryExperimental Neurology, 2009
- Effects of anoxia, aglycemia, and acidosis on cytosolic Mg2+, ATP, and pH in rat sensory neuronsAmerican Journal of Physiology-Cell Physiology, 2008
- Isoflurane preconditioning uncouples mitochondria and protects against hypoxia-reoxygenationAmerican Journal of Physiology-Cell Physiology, 2007
- Bilateral near infrared spectroscopy in space-occupying middle cerebral artery strokeNeurocritical Care, 2007
- Mitochondrial impairment induced by poly(ADP‐ribose) polymerase‐1 activation in cortical neurons after oxygen and glucose deprivationJournal of Neurochemistry, 2005
- Effect of hypothermia on cerebral blood flow and metabolism in the pigThe Annals of Thoracic Surgery, 2002
- Evaluation of a Cerebral Oximeter as a Monitor of Cerebral Ischemia during Carotid EndarterectomyAnesthesiology, 2000